With the new NASA @ WORK opportunity, NASA is seeking additional viable solutions where the agency can make a meaningful difference. For the initial call for ideas, NASA leadership, working with the White House and other government agencies, determined three focus areas around personal protective equipment, ventilation devices, and monitoring and forecasting the spread and impacts of the virus. Other creative ideas are encouraged as well, and as COVID-19 evolves, the NASA @ WORK challenge may introduce additional topic areas to address the needs of the countries.